abstract：:We recently reported that functional loss of p53 altered the responses of human HCT116 colon cancer cells to apoptosis triggers. To examine the molecular basis underlying the differential responses to drug treatment in the cancer cells, we performed a proteomic analysis in order to compare the protein expressions betw...

journal_title：Cancer genomics & proteomics

authors： Lee SC,Chan J

更新日期：2012-03-01 00:00:00

abstract：AIM:Alpha B-Crystallin (CRYAB) is purported to be a metastasis suppressor protein, and lack or lower CRYAB expression is a prognostic biomarker for several types of cancer, such as that of the prostate and head and neck. However, the association of genomic variation of CRYAB and breast cancer is not well studied. The a...

journal_title：Cancer genomics & proteomics

authors： Su CH,Liu LC,Hsieh YH,Wang HC,Tsai CW,Chang WS,Ho CY,Wu CI,Lin CH,Lane HY,Bau DT

更新日期：2011-09-01 00:00:00

abstract：AIM:To identify and study targets of microRNA biomarkers of glioblastoma survival across events (death and recurrence) and phases (life expectancy or post-diagnostic) using functional and network analyses. MATERIALS AND METHODS:microRNAs associated with glioblastoma survival within and across race, gender, recurrence,...

journal_title：Cancer genomics & proteomics

authors： Delfino KR,Serão NV,Southey BR,Rodriguez-Zas SL

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:The transcription factor SOX2 controls gene expression during development and has roles in both neurogenesis and gliogenesis. MATERIALS AND METHODS:The current study utilized immunohistochemistry, immunofluorescence, molecular genetics (gene copy number analysis) and Western blotting to examine SOX2 express...

journal_title：Cancer genomics & proteomics

authors： Annovazzi L,Mellai M,Caldera V,Valente G,Schiffer D

更新日期：2011-05-01 00:00:00

abstract：:The expression profiles of the erythropoietin producing hepatocellular carcinoma (Eph) receptor family of tyrosine kinases have been previously shown to provide molecular signatures of normal breast cells, breast tumor cells and invasive breast carcinoma cells. In particular, the expression of EphB6 receptor is lost i...

journal_title：Cancer genomics & proteomics

authors： Kandpal RP

更新日期：2010-09-01 00:00:00

abstract：:TACC2 is a member of the transforming acidic coiled-coil-containing protein family and is associated with the centrosome-spindle apparatus during cell cycling. The TACC2 gene is expressed in various splice forms predominantly in postmitotic tissues, including heart, muscle, kidney, and brain. Recent work has shown tha...

journal_title：Cancer genomics & proteomics

authors： Cheng S,Douglas-Jones A,Yang X,Mansel RE,Jiang WG

更新日期：2010-03-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT) is overexpressed in prostate cancer. Estrogen plays a central role in the development of prostate cancer. hTERT activity has been shown to be increased after estrogen treatment. Although significant efforts have been made to understand the role of estrogen, the telomerase...

journal_title：Cancer genomics & proteomics

authors： Chen J,Huang P,Kaku H,Zhang K,Watanabe M,Saika T,Nasu Y,Kumon H

更新日期：2009-11-01 00:00:00

abstract：:Tumorigenesis of glioblastoma multiforme (GBM), the most aggressive primary intracranial neoplasm, is associated with aberrant PI3K/AKT/mTOR signaling. Inhibitors of mTOR, such as rapamycin (RAPA) or its analogs, have provided limited benefit. Here, we aim to decipher the signaling pathways involved in RAPA resistance...

journal_title：Cancer genomics & proteomics

authors： Albert L,Karsy M,Murali R,Jhanwar-Uniyal M

更新日期：2009-09-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related to death in both men and women. Protein biomarkers for lung cancer were investigated using the expression of proteins from lung cancer cell line (A549) and compared with those of normal lung fibroblast cell line (MRC-5). Two-dimensional gel electrophoresis of A549 and...

journal_title：Cancer genomics & proteomics

authors： Rubporn A,Srisomsap C,Subhasitanont P,Chokchaichamnankit D,Chiablaem K,Svasti J,Sangvanich P

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Patients with metastazing malignant melanoma have a poor outcome and determination of thickness of the primary tumor remains as the most important prognostic predictor. The aim of this study was to use an antibody-based proteomics strategy to search for new molecular markers associated with melanoma progress...

journal_title：Cancer genomics & proteomics

authors： Bolander A,Agnarsdóttir M,Strömberg S,Ponten F,Hesselius P,Uhlen M,Bergqvist M

更新日期：2008-11-01 00:00:00

abstract：:Cellular signal transduction pathways and gene expression are tightly regulated to accommodate changes in response to physiological environments. In the current study, molecules were identified that are activated as a result of intracellular signaling and immediately expressed as mRNA in MCF-7 breast cancer cells shor...

journal_title：Cancer genomics & proteomics

authors： Nagashima T,Oyama M,Kozuka-Hata H,Yumoto N,Sakaki Y,Hatakeyama M

更新日期：2008-05-01 00:00:00

abstract：:Previous studies have suggested that galectin-3 expression was markedly elevated in papillary thyroid carcinoma compared to other thyroid diseases. In order to better understand this protein, galectin-3 from papillary thyroid carcinoma was partially purified by affinity chromatography on lactose-agarose. Proteins elut...

journal_title：Cancer genomics & proteomics

authors： Sawangareetrakul P,Srisomsap C,Chokchaichamnankit D,Svasti J

更新日期：2008-03-01 00:00:00

abstract：:After the completion of sequencing for dozens of genomes, as well as the draft of human genome, a major challenge is to characterize genome-wide transcriptional regulation networks. Identification of regulatory functions for transcription factor binding sites in eukaryotes greatly enhances our understanding of the net...

journal_title：Cancer genomics & proteomics

authors： Chen X,Zhang H

更新日期：2008-01-01 00:00:00

abstract：UNLABELLED:A growing body of evidence suggests that early growth response-1 (Egr-1), a transcription factor, may function as a tumor suppressor. The aim of this study was to gain more evidence to support the role of Egr-1 in the suppression of cancer cell growth and to examine the potential correlation between Egr-1 an...

journal_title：Cancer genomics & proteomics

authors： Liu J,Liu YG,Huang R,Yao C,Li S,Yang W,Yang D,Huang RP

更新日期：2007-11-01 00:00:00

abstract：:Testicular germ cell tumors (GCT) are the most frequent malignancy in young adults and arise from intratubular germ cell neoplasia undetermined (IGCNU, also referred to as carcinoma in situ, CIS). To determine the transcriptional programs involved in the transition from normal germ cells to GCT, and to further elucida...

journal_title：Cancer genomics & proteomics

authors： Biermann K,Heukamp LC,Steger K,Zhou H,Franke FE,Sonnack V,Brehm R,Berg J,Bastian PJ,Muller SC,Wang-Eckert L,Buettner R

更新日期：2007-09-01 00:00:00

abstract：:Functional genomics has been applied in the study of human malignancies since the inception of this field nearly a decade ago. Microarray analysis has been specifically used in an attempt to re-classify carcinomas at the molecular level, to aid in diagnosis/prognosis and to predict how various types of tumour respond ...

journal_title：Cancer genomics & proteomics

authors： Roberts ML,Kottaridis SD

更新日期：2007-07-01 00:00:00

abstract：:The concept of individualized cancer chemotherapy emerged three decades ago from the observation that a small fraction of cells in primary tumors can form colonies in soft agar similar to stem cells of the hematopoietic system. In a series of retrospective and prospective clinical studies, clonogenic tumor growth and ...

journal_title：Cancer genomics & proteomics

authors： Chumsri S,Phatak P,Edelman MJ,Khakpour N,Hamburger AW,Burger AM

更新日期：2007-05-01 00:00:00

abstract：:In the present review, we give a short introduction into the history, philosophy and traditional diagnosis and therapy of Kampo, which has its origins in traditional Chinese medicine. The main focus is on pharmacogenomics of natural products derived from Kampo medicinal plants, with special emphasis on cancer treatmen...

journal_title：Cancer genomics & proteomics

authors： Efferth T,Miyachi H,Bartsch H

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Inositol hexakisphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has been reported to have significant in vivo and in vitro anticancer activity against numerous tumors. However, the molecular mechanism of the anticancer effect of IP6 has not been fully elucidated. MATERIALS AND METHOD...

journal_title：Cancer genomics & proteomics

authors： Bozsik A,Kökény S,Olah E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Clinical observations indicate that tumour cells can acquire tolerance when an anticancer drug is administered repeatedly. In the present study, the gene expression in cisplatin-resistant cells was analysed to identify early changes in gene expression in the course of cisplatin exposure. MATERIALS AND METHO...

journal_title：Cancer genomics & proteomics

authors： Takazawa K,Tsuchiya H,Yoshimichi U,Kanazawa Y,Ii S,Tomita K

更新日期：2006-11-01 00:00:00

abstract：:Although several microscopic techniques are available for separation of small groups of cells from surrounding tissue, the high energy concentrated into a small area, the easy control of beam position and the lack of direct contact with the material to be dissected make lasers the best option for a large scale microdi...

journal_title：Cancer genomics & proteomics

authors： Ahmed FE

更新日期：2006-05-01 00:00:00

abstract：:The small heterodimer partner (SHP) is a key regulator of genes involved in cholesterol-bile acid homeostasis and functions as a specific transcription repressor. Differential protein expression in the liver of transgenic mice expressing the human SHP gene was compared with wild-type animals. Liver protein extracts we...

journal_title：Cancer genomics & proteomics

authors： Kouyianou K,Garbis S,Boulias K,Dimitraki P,Fountoulakis M,Tsiotis G

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Genetic differences between pulmonary typical carcinoids (TCs) and atypical carcinoids (ATCs) still remain controversial and no genetic marker is available for the evaluation of the malignant potential in pulmonary carcinoids. MATERIALS AND METHODS:Five TCs and 3 ATCs were analyzed concurrently by comparati...

journal_title：Cancer genomics & proteomics

authors： Inamura K,Furuta R,Satoh Y,Shirakawa T,Okumura S,Nakagawa K,Fujiwara M,Tsuchiya E,Ishikawa Y

更新日期：2006-01-01 00:00:00

abstract：:Soft tissue sarcomas are rare, heterogeneous, mesenchymal tumors that have been poorly classified. The heterogeneity of these aggressive tumors has made consistent tumor grading difficult and accurately predicting the behavior of the tumor based on the histological subtype and grade has been challenging. Molecular pro...

journal_title：Cancer genomics & proteomics

authors： Caldwell RL,Holt GE,Caprioli RM

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Paclitaxel and docetaxel affect microtubule polymerization, yet surprising differences in tumor sensitivity to the taxanes have been observed. Docetaxel was superior to paclitaxel in inhibiting in vivo growth of human lung and prostate but not breast cancer models. MATERIALS AND METHODS:We compared drug cyt...

journal_title：Cancer genomics & proteomics

authors： Izbicka E,Campos D,Carrizales G,Tolcher A

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Identification and characterization of genes that are relevant to pancreatic cancer remains a priority for developing detection and diagnostic tests and identifying targets for treatment. MATERIALS AND METHODS:In order to discover relevant genes, we developed a microarray composed of 5763 pancreas and pancr...

journal_title：Cancer genomics & proteomics

authors： Pogue-Geile KL,Mackey JA,George RD,Wood PG,Lee KKW,Moser AJ,Tillman DL,Lyons-Weiler J,Whitcomb DC

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Breast cancer metastasis is associated with the motility and invasiveness of breast cancer cells. In a previous study we reported the motility enhancement effect of keratinocyte growth factor (KGF) on breast cancer cells. This study established and characterized the influence of KGF on breast cancer cell mot...

journal_title：Cancer genomics & proteomics

authors： Zang XP,Lerner ML,DO SV,Brackett DJ,Pento JT

更新日期：2004-07-01 00:00:00

abstract：:Epidemiological studies have established a causal relationship between cigarette smoking and respiratory tract cancer. The knowledge about the interaction of tobacco constituents with cellular systems is, however, still incomplete. Therefore, we analyzed 36 factors with known or assumed relevance and found that 8 prot...

journal_title：Cancer genomics & proteomics

authors： Efferth T,Koomägi R,Mattern J,Volm M

更新日期：2004-05-01 00:00:00

abstract：:Although the statistical probability of therapeutic success is known for larger groups of cancer patients, the clinical response to chemotherapy of the individual patient remains uncertain. It would be of great value to know whether or not an individual tumor responds to the proposed therapy. The concept of sensitivit...

journal_title：Cancer genomics & proteomics

authors： Volm M,Koomagi R,Efferth T

更新日期：2004-03-01 00:00:00

abstract：:We present possible applications of Atomic Force Microscopy (AFM) as a force spectroscopy tool in genomics and proteomics. AFM applications in these fields have opened new opportunities for studying the mechanical properties of biomolecules and their interactions in their native environment, as well as in determining ...

journal_title：Cancer genomics & proteomics

authors： Costa LT,Thalhammer S,Heckl WM

更新日期：2004-01-01 00:00:00